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Nevertheless, if you gain or lose weight while taking Buspar and/or want to minimize further weight change, consider implementing some of the weight management strategies discussed below.. Information at the site cannot be used for self-treatment and self-diagnosis. Consult your doctor concerning proper dose for you. whereas in the rats that received buspirone weight gain was.5 grams (0.1 lbs.).. If youve used Buspar for a moderate duration, leave a comment noting whether youve experienced weight change that you believe is attributable to the medication.. For example, if Buspar is causing somnolence that leads to weight gain, then the concurrent use of a stimulatory agent like caffeine may prevent weight gain by offsetting the somnolence. By using the lowest effective dose, the risk of side effects like weight change should decrease. The increases in prolactin secretion are dose-dependent, but the increase in growth hormone is not contingent upon dose.. 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